ARC |
Arca inflata hemocidins |
Epidermal growth factor-binding protein 2 |
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The monoclonal antibody anti-Arc-1 perturbs specific cell-cell contacts of MDCK epithelial cells in tissue culture. The cells loosen their tight junctions, become uncoupled, and their polarity is abolished. The corresponding antigen appears to be a cell surface protein of MDCK epithelial cells but not of other established cell lines. Behrens et al (1983) have shown that the antibody recognizes a molecule that strongly resembles uvomorulin, making it likely that the corresponding antigen is identical to E-cadherin. Gallin et al (1987) have stated that the biochemical properties and tissue distributions of chicken L-CAM
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