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[viral OX2] This glycosylated cell surface protein protein of 55 kDA is encoded by the open reading frame K14 of the Kaposi sarcoma-associated herpesvirus, KSHV. The protein has significant homology with cellular OX2 antigen expressed in a variety of cell types. A similar gene has been detected also in the genome of rat CMV (cytomegalovirus OX2 protein) (Voigt et al, 2005).
vOX2 triggers the production of the inflammatory cytokines IL1-beta, IL6, MCP-1, and TNF-alpha by primary monocytes, macrophages, and
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