Guanylate cyclase C activating peptide 2 |
Guanylyl cyclase-activating protein 1 |
CED3 protease suppressor-5 |
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abbr. GN. Human Guanylin is a small peptide of 15 amino acids (PGTCEICAYAACTGC) derived from a larger precursor (Hamra et al, 1996). The protein is structurally related to Uroguanylin and Lymphoguanylin. The peptide contains four conserved cysteines. Guanylin was isolated initially from rat intestine as an activity that stimulates cGMP production in T84 intestinal cells (Currie et al, 1992). The bioactive peptide
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