Gamma-Heregulin |
gammaherpesvirus 68 chemokine binding protein |
UNC5D(254-272) |
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abbr. gHV68 BCL2. This protein is encoded by murine gammaherpesvirus 68 open reading frame M11 (a term with multiple meanings) [gammaherpesvirus 68 M11 protein] (Virgin et al, 1997). The protein has limited homology to the BCL2 family of proteins, contains a BH1 domain, but apparently lacks a BH2 domain and inhibits cell death by apoptosis induced by antibodies against FAS and by TNF-alpha following transfection into HeLa cells (Wang et al, 1999).
Roy et al (2000) have shown that gammaherpesvirus 68 BCL2 protects murine
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