ESP13.6 |
EspJ |
KARS |
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[EPEC secreted protein F; Escherichia coli-secreted protein F; Escherichia coli -secreted protein F] espF is one of several genes encoded by a pathogenicity island in the enteropathogenic Escherichia coli chromosome known as the LEE [locus of enterocyte effacement] (Elliott et al, 1998; McDaniel et al, 1995; for overview see also: Wong et al, 2011, Dean and Kenny, 2009). EspF is a secreted virulence factor (McNamara BP and Donnenberg, 1998) that disrupts intestinal barrier functions by disrupting tight junctions without involvement in attaching and effacing lesion formation (McNamara et al, 2001).
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