crmD |
CRNs |
casein-beta(74-76) |
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[cytokine response modifier E] CrmE is encoded by cowpox virus (Saraiva and Alcami, 2001; Cunnion et al, 1999). crmE is expressed as a secreted protein of 18 kDa, The protein binds human, mouse, and rat TNF, but not human LT-alpha, conjugates of LT-alpha and LT-beta. It also does not bind to other ligands of the TNF superfamily tested (4-1BBL, BAFF, CD40L, GITR, RANK, TRAIL, TWEAK).
crmE blocks the binding of TNF to high-affinity TNF receptors
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