AGE |
Age-associated microRNAs |
IL1raBF |
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[age-associated B-cell]
abbr. ABCs. This subset of murine B-cells, characterized as CD21(-) CD35(-) CD23(-) CD43(-) CD19(+), has been identified as B-cells that do not express markers that characterise follicular B-cells, marginal zone B-cells, B-1 B-cells, and transitional B-cells (Hao et al, 2011). These cells comprise up to 30 % of mature B-cells by 22 months. The cells are refractory to BCR and CD40 stimulation and respond to TLR9 or TLR7
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