TGH-1 |
TGI |
S-cells |
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[TGF-beta homolog-2] The gene encoding this protein has been isolated from the filarial nematodes Brugia malayi (designated Bm-TGH-2 [Brugia malayi TGF-beta homolog-2]). TGH-2 is closely related to Caenorhabditis elegans DAF7 and to human TGF-beta.
Expression of TGH-2 mRNA is maximal in the microfilarial stage. TGH-2 is secreted by adult worms in vitro. Recombinant TGH-2 shows a low level of binding to TGF-beta receptor and can be inhibited partially by human TGF-beta. In miNK-cells expressing the TGF-beta receptor, TGH-2 activates plasminogen activator inhibitor-1
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