pan-hematopoietic expression gene X |
pannocytes |
HuLy-m4 |
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abbr. PNT-1. This is a synthetic trophic factor (see also: Neurotrophins) engineered by combining active domains of NGF, BDNF and NT-3 into an NT-3 backbone (Ibáñez et al, 1993). The engineered multifunctional protein efficiently activates all trk receptors and efficiently blocks the chemical crosslinking of NGF, BDNF, and NT-3 to their cognate trk receptors and to the low-affintiy NGF receptor expressed on neuronal and nonneuronal cells (Ilag et al, 1995).
The molecule displays multiple neurotrophic specificities, including survival of a number of
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