PBSC |
pburs |
Megakaryoblast growth factor |
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[pre-B-cell growth stimulating factor] This factor of 89 amino acids is found in the conditioned medium of the stromal cell line, PA6 (see also: BMC, bone marrow culture) (Nagasawa et al, 1994).
PBSF is a member of the family of chemotactic cytokines known as Chemokines (Alpha-Chemokines). It is distinct from SCF (stem cell factor) and IL7 and supports the proliferation of a stromal cell-dependent pre-B-cell line DW34. PBSF synergistically augments the growth of DW34 cells and bone marrow B-cell progenitors in the presence of
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