Notch-4

[Neurogenic locus notch homolog protein 4, Notch receptor 4] one of the genes related to Notch. This gene is known also as int-3 (renamed notch-4 by Shirayoshi et al, 1997), identified initially as a cellular oncogene, the expression of which is activated by the integration of mouse mammary tumor virus sequences into neighboring chromosomal DNA. int-3 encodes a transmembrane protein. Human Notch-4 (Li et al, 1998) is a protein of 2003 amino acids displaying 82 % identity with the murine protein. The designation Notch-4 has been proposed for the full-length protein by Uyttendaele et al (1996), who cloned the ... ... ... ...
 
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Entry last modified: January 2004