Edg |
EDG5 |
Neuromedin S |
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[endothelial differentiation gene 1] This is another designation for S1PR1 [sphingosine-1-phosphate receptor 1] (for receptor nomenclature see also: Chun et al, 2002).
EDG1 is a gene cloned and sequenced from a human umbilical vein endothelial cell library (Hla and Maciag, 1990). EDG1 transcripts are induced rapidly and abundantly in response to treatment of endothelial cells are treated with phorbol 12-myristate 13-acetate, which is known to inhibit the growth of human endothelial cells and to induce differentiation into capillary-like, tubular structures.
The deduced protein of 380 amino acids is structurally similar to
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