Chaperone-assisted selective autophagy |
Chaperones |
proteoglycan M-CSF |
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abbr. CMA. This term pertains to the import and degradation of soluble cytosolic proteins by direct translocation across the lysosomal membrane in a manner that depends on chaperone proteins that deliver the cargo proteins to the surface of lysosomes. Unlike general autophagy, which is a bulk degradation process, Chaperone-mediated autophagy involves individual recognition of single proteins and unfolding of substrate proteins before degradation by lysaosomal hydrolases (Cuervo, 2011; for overview see: Kaushik and Cuervo, 2012; Huber and Teis, 2016; Arias, 2017). Chaperone-mediated autophagy, unlike Chaperone-assisted selective autophagy, does not require ubiquitination of the substrates and relies on BAG3 [BCL2-associated athanogene-3].
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