Anaphylatoxin C5a |
Anaphylaxis inhibitory factor |
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[Anaphylatoxin]
This term refers to bioactive fragments generated during activation of the blood complement system. They are derived by enzymatic cleavage by specific convertases from the serum proteins complement component C3 (anaphylatoxin C3a) and complement component C5 (anaphylatoxin C5a), and anaphylatoxin C4a from complement component C4.
Anaphylatoxins release histamine from mast cells, cause smooth muscle contraction, enhance vascular permeability, produce edema and erythema upon intradermal injection, and may lead to a fatal reaction resembling anaphylactic shock in experimental animals.
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