Allograft inflammatory factor-1 |
ALLP1 |
broad spike neurons |
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This antimicrobial peptide with the sequence AAVTRRILCWFAamide has been identified in the dynastid Beetle, Allomyrina dichotoma. Allomyrinasin binds to bacterial cell membranes via a specific interaction with lipopolysaccharides and shows antimicrobial and anti-inflammatory activities in mouse macrophage Raw264.7 cells. Allomyrinasin shows potent antimicrobial activity against Escherichia coli and Staphylococcus aureus, but relatively weak activity against Propionibacterium acnes, Staphylococcus epidermidis, and Candida albicans. Allomyrinasin decreases the production of IL6 and IL1-beta
but not that of TNF-alpha, and also decreases nitric oxide production induced by
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