APAF-1-ALT |
APAF-1L |
RNA helicase associated with AU-rich element ARE |
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abbr. AIP. This rat gene product functions as a dominant-negative inhibitor of the apoptosis pathway involving APAF-1 and caspase-9. AIP is expressed constitutively in the brain, but at substantially lower levels than APAF-1 and caspase-9. Direct interaction of this protein with APAF-1 through its N-terminal CARD domain is increased in cells undergoing cell death by apoptosis. Enforced expression of the protein suppresses apoptosis induced by various pro-apoptotic
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