AGHTKKAP |
Aging-associated gene 4 protein |
Monocyte chemotactic and activating factor |
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[Adipogenesis inhibitory factor] This factor of 178 amino acids is produced as a precursor of 199 amino acids. Purified AGIF inhibits the process of adipogenesis in mouse 3T3-L1 pre-adipocytes. AGIF inhibits the differentiation of bone marrow pre-adipocytes into adipocytes (Ohsumi et al, 1991).
The cDNA has been isolated from a library established from the human bone marrow stromal cell line KM102 (see also: BMC, bone marrow culture) and is identical with IL11 (Kawashima et al, 1991).
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