AEFHRWSSYWVHWK |
Aeg2 |
culekinin depolarizing peptides |
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[astrocyte elevated gene-1] The approved gene symbol is MTDH [metadherin].
AEG-1 has been implicated in tumor progression and affects cell transformation, evasion of cell death by apoptosis, cell invasion and metastasis, and chemoresistance (Hu et al, 2009).
AEG-1 expression is seen in primary human fetal astrocytes infected with HIV1 or treated with gp120 or TNF-alpha (Su et al, 2002, 2003, Kang et al, 2005; Emdad et al, 2006). AEG-1 expression increases anchorage-independent growth and invasiveness of tumor cells and increases expression of adhesion molecules by activating the NF-kappa-B
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