A238L |
A375-C5 |
IL1-beta Convertase |
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A human amelanotic melanoma cell line that has been used for a variety of studies in cell biology. A375-6 (A375-C6) is a frequently used subline that responds to IL1. A375-C6 is a subline that is resistant against IL1. A375-R is a subline selected for TNF resistance.
The growth of A375 cells is inhibited by IL1-alpha or IL1-beta at concentrations of 10-30 pg/mL, which cause growth arrest in phase G0/G1 of the cell cycle. Accordingly, A375 cells have been used in research on cytokines for bioassays
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